Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics

M Garcia-Closas; P Hall; H Nevanlinna; K Pooley; J Morrison; DA Richesson; SE Bojesen; BG Nordestgaard; CK Axelsson; JI Arias; RL Milne; G Ribas; A González-Neira; J Benítez; P Zamora; H Brauch; C Justenhoven; U Hamann; YD Ko; T Bruening; S Haas; T Dörk; P Schürmann; P Hillemanns; N Bogdanova; M Bremer; JH Karstens; R Fagerholm; K Aaltonen; K Aittomäki; K Von Smitten; C Blomqvist; A Mannermaa; M Uusitupa; M Eskelinen; M Tengström; VM Kosma; V Kataja; G Chenevix-Trench; AB Spurdle; J Beesley; X Chen; P Devilee; CJ Van Asperen; CE Jacobi; RAEM Tollenaar; PEA Huijts; JGM Klijn; J Chang-Claude; S Kropp; T Slanger; D Flesch-Janys; E Mutschelknauss; R Salazar; S Wang-Gohrke; F Couch; EL Goode; JE Olson; C Vachon; ZS Fredericksen; GG Giles; L Baglietto; G Severi; JL Hopper; DR English; MC Southey; CA Haiman; BE Henderson; LN Kolonel; L Le Marchand; DO Stram; DJ Hunter; SE Hankinson; DG Cox; R Tamimi; P Kraft; ME Sherman; SJ Chanock; J Lissowska; LA Brinton; B Peplonska; MJ Hooning; H Meijers-Heijboer; JM Collee; A Van Den Ouweland; AG Uitterlinden; J Liu; YL Low; L Yuqing; K Humphreys; K Czene; A Cox; SP Balasubramanian; SS Cross; MWR Reed; F Blows; K Driver; A Dunning; J Tyrer; BAJ Ponder

Journal article

Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics

M Garcia-Closas, P Hall, H Nevanlinna, K Pooley, J Morrison, DA Richesson, SE Bojesen, BG Nordestgaard, CK Axelsson, JI Arias, RL Milne, G Ribas, A González-Neira, J Benítez, P Zamora, H Brauch, C Justenhoven, U Hamann, YD Ko, T Bruening Show all

Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2008

DOI: 10.1371/journal.pgen.1000054

Abstract

A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in F..

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